Protein Details: Acid-sensing ion channel 4

Protein ID

ICDB_Pro_1522

Protein Name

Acid-sensing ion channel 4

Gene Name

Asic4; Accn4; Spasic

Organism

Rattus norvegicus (Rat)

Length

539 amino acids

AlphaFoldDB

AF-Q9JHS6-F1-model_v4.pdb

Function

Probable cation channel with high affinity for sodium.

Sequence

MPIEIVCKIKFAEEDAKPKEKEAGDEQSLLGAAQGPAAPRDLATFASTSTLHGLGRACGPGPHGLRRTLWVLALLTSLAAFLYQAASLARGYLTRPHLVAMDPAAPAPVAGFPAVTLCNINRFRHSALSDADIFHLANLTGLPPKDRDGHRAAGLRYPEPDMVDILNRTGHQLADMLKSCNFSGHHCSASNFSVVYTRYGKCYTFNADPQSSLPSRAGGMGSGLEIMLDIQQEEYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQKQRLTYLPQPWGNCRAESKLREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMPGNETICPPNIYIECADHTLDSLGGGSEGPCFCPTPCNLTRYGKEISMVKIPNRGSARYLARKYNRNETYIRENFLVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIYEVSWDRLKRVWRRPKTPLRTSTGGISTLGLQELKEQSPCPNRGRAEGGGASNLLPNHHHPHGPPGSLFEDFAC

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Expressed in brain; spinal cord and dorsal root ganglion (DRG). Expressed by a subset of sensory neurons in the DRG. Expressed by granule cells in the cerebellar cortex. Expressed by granule cells in the cerebellar cortex. Expressed by granule cells in the cerebellar cortex. In hippocampus; expression is detected in dentate gyrus granule cells; in pyramidal cells of CA1-CA3 subfields and in interneurons of the striatum oriens and radiatum of all subfields. In cerebral cortex expressed in small; medium and large pyramidal cells in layers 2; 3 and 5 respectively. Also expressed in striatum; globus pallidus; inferior and superior calliculi; amygdala; magnocellular preoptic nucleus; islands of Calleja and large neurons of olfactory tubercules.

DOI ID

10.1097/00001756-200006050-00003; 10.1097/00001756-200007140-00031

RefSeq

NP_071570.2